Prep SFC M5-250

Versatile SFC System for Chiral and Achiral Separations

Prep SFC M5

Sepiatec‘s new Prep SFC M5-250 system is a preparative system for separating chiral and achiral samples using supercritical fluid chromatography. The Prep SFC M5 system consists of the main module and the collector module. Both modules form a functional unit that can be configured in a variety of ways with different equipment.

  • 150 ml pumps for CO2 and organic modifiers
  • Max. flow rate 250 ml/ min (isocratic), 150 ml/ min (gradient)
  • Column oven for 10 columns with 15 to 30 mm ID
  • Various fraction collectors available, up to 195 fractions
  • Easy to operate software, stack functions, on-the-fly editing
  • Build-in system controller, no additional PC required
  • Big 15.6” touch screen


Prep SFC M5-250 System With Sorter Module

Possibilities for collecting and processing fractions using the Prep SFC M5-50 system can be expanded with the optional sorter module. The sorter module is a handling robot designed for interacting with the collector module of the Prep SFC M5 system. It is available in a variety of different sizes and can be equipped with various gripper arms. A wide range of variants and functions is possible with the addition of various components:

  • Continuous removal of vials from the collector module with sorting according to pre-selected criteria
  • Continuous placement of new empty vials into the holder of the collector module, thus expanding the collection capacity to several hundred fractions
  • Weighing of vials that are removed from the collector module, which are then to be dried in an evaporator, automatic preparation of a “counter vial” with identical weight, positioning of both vials in the holding tray of the evaporator
  • A variety of other sample preparation processes for further analysis of collected fractions

Prep SFC M5-250 Software

The Prep SFC M5-250 system is controlled entirely by means of the Prep SFC control software which offers a clear menu structure enabling simple and intuitive operation. All input options are presented on just a few screens. The software includes a sequence editor for inputting separation parameters for different samples, functions such as stack injection with automatic suggestions for stack times and multiple options for fractionation. A computer at a separate work site can also be connected. If an optional mass spectrometer is used, control and data acquisition also take place directly via the Prep SFC control software.

  • Subject to modifications.

Operating mode 1 semi-preparative or preparative column
Suitable columns 15 to 30 mm ID, max. 250 mm in length
Solvents CO2 and organic solvents
Number of modifier solvents 1 standard, max. 4 with optional selection valve
CO2 pump 150 ml pump head, 400 bar
Modifier pump 150 ml pump head, 400 bar
Add-on pump 30 ml pump head, 400 bar (optional)
Total flow rate, isocratic 250 ml/ min at a modifier portion of 40%
Total flow rate, gradient 150 ml/ min
Backpressure range Up to 300 bar, adjustable online backpressure control
Injection Partial loop with syringe pump
Column oven Ambient temperature to 70° C, 10 columns
UV Detector Wavelength range 190 to 500 nm
Other detectors DAD, ELSD or mass spectrometer optional
Fraction collector Carousel collector: fraction volumes 10 to 500 ml,
XY-collector: 72 vials 60 ml or 195 vials 10 ml,
other fraction collectors available on request
Software Prep SFC control software
System controller Integrated PC, Windows, 15.6” TFT touch-screen
Connections 3 USB ports, Ethernet, HDMI
Dimensions, weight 91.5 x 60 x 88 cm (W x D x H), 148 kg

Specifications subject to change without notice.

Technical data of the Prep SFC M5 sorter module available on request