The ability to perform mixing of samples is a critical process for all types of applications in chemistry, biology, and sample preparation. Mixing is important for the dissolution of solids into liquid and to perform the complete mixing of multiple liquids in order to perform a synthesis reaction or to enable a biochemical assay.
The Zinsser Desyre vortexer is the core mixing product developed by Zinsser. It was created to satisfy the stringent requirements for complete mixing under temperature-controlled conditions that are necessary for automated solid phase synthesis, where insufficient mixing can result in low yields and poor results. The Desyre vortexer is available as a standalone unit or can be integrated onto any Zinsser liquid handler deck. It can be configured for heating while vortexing up to 250 deg C or for cooling while vortexing down to -80 deg C. Shown below is an external module with 4 heated vortexers and 1 cooled vortexer. The vortexers also feature automatically-actuated clamps to hold the labware in place during vortexing, provididn compatability with the robot grippers used to move labware on and off the vortexers.
The Zinsser vortexers have been specially designed with a chaotic movement pattern that ensures thorough mixing of liquid rather than just moving it around. The speed is programmable via the instrument method software.
Sometimes it is desired that one tube or vial be vortexed at a time. In this case, the single tube vortexer can be installed on the deck. A robot gripper is used to place the tube onto the vortexer, and the 4 fingers automatically clamp tthe tube into place for the vortexing operation.
Sometimes stubborn solids will not go into solution with mixing or vortexing, no matter how long or vigorous it is. In this case, the Zinsser sonication bath offers an additional alternative. The robot gripper places the tube in the bath and the sonication is turned on for a preprogrammed time. After the sonication is complete, the gripper moves the tube to a drying station that uses air to remove any remaining liquid on the exterior surface, to prevent possible dripping.
Sonication can be taken a step further for more aggresive mixing by using a sonication probe. The probe is lowered directly into the liquid and then activated for sonication. The probe is then washed and dried prior to the next sample to prevent cross contamination.
Magnetic stirring is another possibility that can be integrated to a Zinsser liquid handler. If a method is best suited to use vessels or vials with magnetic stir bars, a custom stirring plate can be added, with optional temperature control.
Zinsser has also developed an overhead stirring tool that is especially suitable for mixing viscous liquids such as shampoos or gels. It is compatible with 8 25 ml reactors and is software-programmable for stirring rates of 80-300 rpm. It can be heated or cooled, and it is even possible to access the vials during the stirring process with liquid handling probes to add or remove liquid.
Zinsser automated liquid handling platforms are unique on the market because of the selection of high-performance tools that can be installed on the deck. The ability to select from this list of tools allows the user to configure a system that will fully automate the required application, whether it requires liquid handling, powder handling, weighing, heating, cooling, vortexing, pressurization, vacuum, or almost anything that can be imagined.