Lissy - Automation Platform for QuEChERS

Automate the QuEChERS process for pesticide analysis

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As its name suggests, the QuEChERS method (Quick, Easy, Cheap, Effective, Rugged, and Safe) has caused a breakthrough in pesticide residue analysis in the food sector. The QuEChERS method can be taken to a further level with the fully automated liquid handling platform "LISSY" from Zinsser Analytic. LISSY automates all the required steps for sample analysis – weighing in the sample, the precise and reproducible addition and mixing of solvents and reagents, and centrifugation if required. LISSY therefore provides a rapid and error free automated solution for the analysis of pesticide residues in samples using QuEChERS.

  • Precise Liquid Handling
  • Precise and Reproducible Powder Dosage
  • Efficient Mixing
  • Integrated Centrifuge
  • Optional pH-measurement and Adjustment
  • Optional Purification by SPE


An example of a workflow:

Weighing in the Sample

The vials are manually filled and then placed in a rack on the workbench.

Addition of 10ml Acetonitrile and the ISTD solution

Acetonitrile and the internal standard are added as system liquids with the pipetting probes. The storage bottles are stored off the workbench in their original containers.


For through mixing the single tube vortexer TubeMix is used. It has a speed of 2,200 rpm.

Addition of salt mixture

The salt mixtures have either been manually prepared in tubes or automatically prepared using REDI Super. The salt mixtures are carefully added to the samples using REDI Super.


For extraction with the salt mixture, the sample is vortexed thoroughly on the integrated TubeMix.


For the centrifugation step, the centrifuge is placed beneath the workbench and is automatically loaded by the gripper arm. It carefully places the tubes into the centrifuge racks. The centrifuge is automatically started by the WinLISSY software.

Taking an aliquot to the purification tube

After the centrifugation step, an aliquot is taken and transferred to a purification tube which is stored in a rack on the workbench.

Further Mixing


The sample is then again placed into the centrifuge for a final centrifugation step.

Transfer to HPLC Vials for GC/LC/MS

Finally the sample is transferred to HPLC vials for GC/LC/MS. Altternatively the sample can be directly injected into the analysis system.