Prep SFC 660

The Efficient Solution - Preparative SFC System

Prep SFC 660

Sepiatec’s new Prep SFC 660 system is a compact yet large-scale unit designed for preparative separations using supercritical fluid chromatography. The unit has been designed for flow rates of up 667 ml/min may be achieved (in the case of a modifier portion of 40 %).

All of the advantages of the SFC technology are combined: Quick separation, a reduced consumption of organic solvents and thus cost, increased safety and an environmentally friendly process. In spite of its remarkable capacity, the Prep SFC 360 system features a compact design with measurements of 150 x 68 x 178 cm (W x D x H), so that integration within a walk-in laboratory hood does not create any problem. Additionally, below the unit, several large fraction vessels or a safety cabinet for solvents may be placed.

A CO2 and a modifier pump are provided, each of them equipped with a 400 ml pump head and approved for a pressure of 400 bar. Up to three different organic organic modifiers can be mixed and used for separations. A third pump with 150 ml head is also provided which can be used for modifier or as an add-on pump.

Beside the column mounting, the injection valve and the UV flow cell are also integrated within the column oven, which is heatable up to 50 °C. Separation columns with inner diameters between 30 and 50 mm and a length of up to 800 mm can be used.

When working in “Single Mode“, up to 8 fractions can be collected (CO2 flow < 180 ml/min); in “Tandem Mode“ 4 fractions are available (CO2 flow > 180 ml/min).

The collection of the fractions is performed in unpressurized state; therefore screening of the vessels for reasons of safety is not necessary. The fraction volume in the Prep SFC 660 system is not limited. Fractions of any size may be collected and simply be tapped for further processing.

Operating mode 1 preparative column
Solvents CO2 and organic solvents
Number of modifier solvents 3 solvents, mixable, solvent selection valves included
Total flow rates Up to 667 ml/min (40 % modifier)
CO2 pump 400 ml pump head, 400 bar
Modifier pump 400 ml pump head, 400 bar
Modifier/Add-on pump 150 ml pump head, 400 bar
Operating pressure Up to 300 bar, adjustable online backpressure control
Injection Partial and total loop with syringe pump
Columns 30 to 50 mm ID up to 800 mm length
Column oven Ambient temperature to 50° C, 1 column standard, 2 columns with optional valves
Detection UV detector, wavelength 190 to 500 nm, DAD, ELSD or mass spectrometer optional
Fraction collection 1 to 8 fractions (single mode), 1 to 4 fractions (tandem mode)
Software Prep SFC control software
System controller Integrated PC, 15“ TFT touch-screen
Connections 3 USB ports, ethernet, HDMI
Dimensions 150 x 68 x 178 cm (W x D x H)
Weight 350 kg
INTEGRATED WATER COOLED CHILLER Huber Unichiller 015-MPC plus (or successor model)
Temperature range - 20 °C to 40 °C
Temperature consistency ± 0.5 °C
Cooling performance 15 °C / 1.5 KW, 0 °C / 1.0 KW, - 10 °C / 0.7 KW, - 20 °C / 0.3 KW
Cooling device °C / 0.7 KW, - 20 °C / 0.3 KW Air-cooled, CFC- and HCFC-free
Refrigerant R507
Dimensions 42 x 48 x 58 cm (W x D x H)
Weight 52 kg


Specifications subject to change without notice.