Prep SFC 360

The Efficient Solution - Preparative SFC System

Prep SF360

Sepiatec’s new Prep SFC 360 system is a compact yet large-scale unit designed for preparative separations using supercritical fluid chromatography. The unit has been designed for flow rates of up to 360 ml of supercritical fluid per minute. Depending on the modifier portion, even up to 600 ml/min may be achieved (in the case of a modifier portion of 40 %).

All of the advantages of the SFC technology are combined: Quick separation, a reduced consumption of organic solvents and thus cost, increased safety and an environmentally friendly process. In spite of its remarkable capacity, the Prep SFC 360 system features a compact design with measurements of 150 x 68 x 178 cm (W x D x H), so that integration within a walk-in laboratory hood does not create any problem. Additionally, below the unit, several large fraction vessels or a safety cabinet for solvents may be placed.

A CO2 - as well as a modifier pump are provided, each of them equipped with a 360 ml pump head and approved for a pressure of 360 bar. Up to three different organic organic modifiers can be mixed and used for separations.

Beside the column mounting, the injection valve and the UV flow cell are also integrated within the column oven, which is heatable up to 50 °C. Separation columns with inner diameters between 25 and 50 mm and a length of up to 800 mm can be used.

When working in “Single Mode“, up to 8 fractions can be collected (CO2 flow < 180 ml/min); in “Tandem Mode“ 4 fractions are available (CO2 flow > 180 ml/min).

The collection of the fractions is performed in unpressurized state; therefore screening of the vessels for reasons of safety is not necessary. The fraction volume in the Prep SFC 360 system is not limited. Fractions of any size may be collected and simply be tapped for further processing.

Operating mode 1 preparative column CO2 and organic solvents
Solvents CO2 and organic solvents
Number of modifier solvents 3 solvents, mixable
Total flow rates Up to 600 ml/min (40 % modifier)
CO2 pump 360 ml pump head, 360 bar
Modifier pump 360 ml pump head, 360 bar
Operating pressure Up to 300 bar, adjustable online backpressure control
Injection Total loop with syringe pump
Columns 25 to 50 mm ID up to 800 mm length
Column oven Up to 50 °C, integrated heating module, injection valve and UV flow cell
Detection UV detector, wavelength 190 to 500 nm
Fraction collection 1 to 8 fractions (single mode), 1 to 4 fractions (tandem mode)
Software Prep SFC 360 control software
System controller Integrated PC, 15“ TFT touch-screen
Connections 3 USB ports, ethernet
Dimensions 150 x 68 x 178 cm (W x D x H)
Weight 298 kg
INTEGRATED WATER COOLED CHILLER Huber Unichiller 015-MPC plus (or successor model)
Temperature range - 20 °C to 40 °C
Temperature consistency ± 0.5 °C
Cooling performance 15 °C / 1.5 KW, 0 °C / 1.0 KW, - 10 °C / 0.7 KW, - 20 °C / 0.3 KW
Cooling device °C / 0.7 KW, - 20 °C / 0.3 KW Air-cooled, CFC- and HCFC-free
Refrigerant R507
Dimensions 42 x 48 x 58 cm (W x D x H)
Weight 52 kg